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10.1016/j.bbadis.2014.05.028 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2014.05.028 C4165798!4165798 !24892209     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24892209 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24892209 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2014 ; 1842 (10 ): 1971-1980 Nephropedia Template TP {{tp|p=24892209 |t=2014. Protein-protein interactions and genetic diseases: The interactome |pdf=|usr=}}{{24892209 }} gab.com Text Protein-protein interactions and genetic diseases: The interactome JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip Protein-protein interactions mediate essentially all biological processes. Despite the quality of these data being widely questioned a decade ago, the reproducibility of large-scale protein interaction data is now much improved and there is little question that the latest screens are of high quality. Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers. Here, I will review how protein-protein interactions are measured, collected and quality controlled. I discuss how the architecture of molecular protein networks has informed disease biology, and how these data are now being computationally integrated with the newest genomic technologies, in particular genome-wide association studies and exome-sequencing projects, to improve our understanding of molecular processes perturbed by genetics in human diseases. This article is part of a Special Issue entitled: From Genome to Function. Twit Text FOAVip Protein-protein interactions and genetic diseases: The interactome ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip English Wikipedia <ref>{{Cite pmid|24892209 }}</ref> Protein-protein interactions and genetic diseases: The interactome #MMPMID24892209 Lage K Biochim Biophys Acta 2014[Oct]; 1842 (10 ): 1971-1980 PMID24892209 show ga Protein-protein interactions mediate essentially all biological processes. Despite the quality of these data being widely questioned a decade ago, the reproducibility of large-scale protein interaction data is now much improved and there is little question that the latest screens are of high quality. Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers. Here, I will review how protein-protein interactions are measured, collected and quality controlled. I discuss how the architecture of molecular protein networks has informed disease biology, and how these data are now being computationally integrated with the newest genomic technologies, in particular genome-wide association studies and exome-sequencing projects, to improve our understanding of molecular processes perturbed by genetics in human diseases. This article is part of a Special Issue entitled: From Genome to Function. äProtein-protein interactions and genetic diseases: The interactome (epmc).pdf DeepDyve Pubget Overpricing