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10.1038/ncomms15582 http://scihub22266oqcxt.onion/10.1038/ncomms15582 C5472766!5472766 !28593994     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28593994 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (ä): 15582 Nephropedia Template TP {{tp|p=28593994 |t=2017. Protein-directed ribosomal frameshifting temporally regulates gene expression |pdf=|usr=}}{{28593994 }} gab.com Text Protein-directed ribosomal frameshifting temporally regulates gene expression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip Programmed -1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift -1?nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as trans-acting switches to turn frameshifting on or off in response to cellular conditions. Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activated by viral protein 2A. As a result, the frameshifting efficiency increases from 0 to 70% (one of the highest known in a mammalian system) over the course of infection, temporally regulating the expression levels of the viral structural and enzymatic proteins. Twit Text FOAVip Protein-directed ribosomal frameshifting temporally regulates gene expression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28593994 #FOAvip English Wikipedia <ref>{{Cite pmid|28593994 }}</ref> Protein-directed ribosomal frameshifting temporally regulates gene expression #MMPMID28593994 Napthine S ; Ling R ; Finch LK ; Jones JD ; Bell S ; Brierley I ; Firth AE Nat Commun 2017[Jun]; 8 (ä): 15582 PMID28593994 show ga Programmed -1 ribosomal frameshifting is a mechanism of gene expression, whereby specific signals within messenger RNAs direct a proportion of translating ribosomes to shift -1?nt and continue translating in the new reading frame. Such frameshifting normally occurs at a set ratio and is utilized in the expression of many viral genes and a number of cellular genes. An open question is whether proteins might function as trans-acting switches to turn frameshifting on or off in response to cellular conditions. Here we show that frameshifting in a model RNA virus, encephalomyocarditis virus, is trans-activated by viral protein 2A. As a result, the frameshifting efficiency increases from 0 to 70% (one of the highest known in a mammalian system) over the course of infection, temporally regulating the expression levels of the viral structural and enzymatic proteins. |Animals [MESH] |Cell Line [MESH] |Encephalomyocarditis virus/genetics/*metabolism [MESH] |Frameshifting, Ribosomal/*genetics [MESH] |Gene Expression Regulation, Viral/*genetics [MESH] |Inverted Repeat Sequences/*genetics [MESH] |Mesocricetus [MESH] |Nucleic Acid Conformation [MESH] |Open Reading Frames [MESH] |Protein Biosynthesis/*genetics [MESH] |RNA, Messenger/genetics [MESH] |RNA, Viral/biosynthesis/genetics [MESH] |Ribosomes/metabolism [MESH]Protein-directed ribosomal frameshifting temporally regulates gene exp(epmc).pdf DeepDyve Pubget Overpricing