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Protein tyrosine phosphatases in cardiac physiology and pathophysiology
#MMPMID29396779
Wade F
; Belhaj K
; Poizat C
Heart Fail Rev
2018[Mar]; 23
(2
): 261-272
PMID29396779
show ga
More than any other organ, the heart is particularly sensitive to gene expression
deregulation, often leading in the long run to impaired contractile performances
and excessive fibrosis deposition progressing to heart failure. Recent
investigations provide evidences that the protein phosphatases (PPs), as their
counterpart protein kinases, are important regulators of cardiac physiology and
development. Two main groups, the protein serine/threonine phosphatases and the
protein tyrosine phosphatases (PTPs), constitute the PPs family. Here, we provide
an overview of the role of PTP subfamily in the development of the heart and in
cardiac pathophysiology. Based on recent in silico studies, we highlight the
importance of PTPs as therapeutic targets for the development of new drugs to
restore PTPs signaling in the early and late events of heart failure.
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