Protein quality control in the nucleus
#MMPMID27015023
Jones RD
; Gardner RG
Curr Opin Cell Biol
2016[Jun]; 40
(?): 81-89
PMID27015023
show ga
The nucleus is the repository for the eukaryotic cell's genetic blueprint, which
must be protected from harm to ensure survival. Multiple quality control (QC)
pathways operate in the nucleus to maintain the integrity of the DNA, the
fidelity of the DNA code during replication, its transcription into mRNA, and the
functional structure of the proteins that are required for DNA maintenance, mRNA
transcription, and other important nuclear processes. Although we understand a
great deal about DNA and RNA QC mechanisms, we know far less about nuclear
protein quality control (PQC) mechanisms despite that fact that many human
diseases are causally linked to protein misfolding in the nucleus. In this
review, we discuss what is known about nuclear PQC and we highlight new questions
that have emerged from recent developments in nuclear PQC studies.
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