Protein networks and activation of lymphocytes
#MMPMID25687331
Helou YA
; Salomon AR
Curr Opin Immunol
2015[Apr]; 33
(?): 78-85
PMID25687331
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The signal transduction pathways initiated by lymphocyte activation play a
critical role in regulating host immunity. High-resolution mass spectrometry has
accelerated the investigation of these complex and dynamic pathways by enabling
the qualitative and quantitative investigation of thousands of proteins and
phosphoproteins simultaneously. In addition, the unbiased and wide-scale
identification of protein-protein interaction networks and protein kinase
substrates in lymphocyte signaling pathways can be achieved by mass
spectrometry-based approaches. Critically, the integration of these
discovery-driven strategies with single-cell analysis using mass cytometry can
facilitate the understanding of complex signaling phenotypes in distinct
immunophenotypes.
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