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2017 ; 2017
(ä): 1729301
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Protein Function Prediction Using Deep Restricted Boltzmann Machines
#MMPMID28744460
Zou X
; Wang G
; Yu G
Biomed Res Int
2017[]; 2017
(ä): 1729301
PMID28744460
show ga
Accurately annotating biological functions of proteins is one of the key tasks in
the postgenome era. Many machine learning based methods have been applied to
predict functional annotations of proteins, but this task is rarely solved by
deep learning techniques. Deep learning techniques recently have been
successfully applied to a wide range of problems, such as video, images, and
nature language processing. Inspired by these successful applications, we
investigate deep restricted Boltzmann machines (DRBM), a representative deep
learning technique, to predict the missing functional annotations of partially
annotated proteins. Experimental results on Homo sapiens, Saccharomyces
cerevisiae, Mus musculus, and Drosophila show that DRBM achieves better
performance than other related methods across different evaluation metrics, and
it also runs faster than these comparing methods.