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10.3390/ijms160613106 http://scihub22266oqcxt.onion/10.3390/ijms160613106 C4490488!4490488 !26068237     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26068237 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26068237 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (6 ): 13106-40 Nephropedia Template TP {{tp|p=26068237 |t=2015. Protein Crystallography in Vaccine Research and Development |pdf=|usr=}}{{26068237 }} gab.com Text Protein Crystallography in Vaccine Research and Development JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26068237 #FOAvip The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structures of complexes between antigens and their cognate neutralizing, or protective, antibody fragments. Most importantly, we provide recent examples where structural insights obtained via protein crystallography have been used to design novel optimized vaccine antigens. This review aims to illustrate the value of protein crystallography in the emerging discipline of structural vaccinology and its impact on the rational design of vaccines. Twit Text FOAVip Protein Crystallography in Vaccine Research and Development ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26068237 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26068237 #FOAvip English Wikipedia <ref>{{Cite pmid|26068237 }}</ref> Protein Crystallography in Vaccine Research and Development #MMPMID26068237 Malito E ; Carfi A ; Bottomley MJ Int J Mol Sci 2015[Jun]; 16 (6 ): 13106-40 PMID26068237 show ga The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structures of complexes between antigens and their cognate neutralizing, or protective, antibody fragments. Most importantly, we provide recent examples where structural insights obtained via protein crystallography have been used to design novel optimized vaccine antigens. This review aims to illustrate the value of protein crystallography in the emerging discipline of structural vaccinology and its impact on the rational design of vaccines. |Amino Acid Sequence [MESH] |Antigens, Bacterial/*chemistry/immunology [MESH] |Antigens, Viral/*chemistry/immunology [MESH] |Binding Sites, Antibody [MESH] |Crystallography [MESH] |Epitopes/*chemistry/immunology [MESH] |Molecular Sequence Data [MESH]Protein Crystallography in Vaccine Research and Development (epmc).pdf DeepDyve Pubget Overpricing