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10.1111/imr.12475 http://scihub22266oqcxt.onion/10.1111/imr.12475 C5432642!5432642 !27782321     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27782321 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2016 ; 274 (1 ): 152-171 Nephropedia Template TP {{tp|p=27782321 |t=2016. Protection of host cells by complement regulators |pdf=|usr=}}{{27782321 }} gab.com Text Protection of host cells by complement regulators JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782321 #FOAvip The complement cascade is an ancient immune-surveillance system that not only provides protection from pathogen invasion but has also evolved to participate in physiological processes to maintain tissue homeostasis. The alternative pathway (AP) of complement activation is the evolutionarily oldest part of this innate immune cascade. It is unique in that it is continuously activated at a low level and arbitrarily probes foreign, modified-self, and also unaltered self-structures. This indiscriminate activation necessitates the presence of preformed regulators on autologous surfaces to spare self-cells from the undirected nature of AP activation. Although the other two canonical complement activation routes, the classical and lectin pathways, initiate the cascade more specifically through pattern recognition, their activity still needs to be tightly controlled to avoid excessive reactivity. It is the perpetual duty of complement regulators to protect the self from damage inflicted by inadequate complement activation. Here, we review the role of complement regulators as preformed mediators of defense, explain their common and specialized functions, and discuss selected cases in which alterations in complement regulators lead to disease. Finally, rational engineering approaches using natural complement inhibitors as potential therapeutics are highlighted. Twit Text FOAVip Protection of host cells by complement regulators ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27782321 #FOAvip English Wikipedia <ref>{{Cite pmid|27782321 }}</ref> Protection of host cells by complement regulators #MMPMID27782321 Schmidt CQ ; Lambris JD ; Ricklin D Immunol Rev 2016[Nov]; 274 (1 ): 152-171 PMID27782321 show ga The complement cascade is an ancient immune-surveillance system that not only provides protection from pathogen invasion but has also evolved to participate in physiological processes to maintain tissue homeostasis. The alternative pathway (AP) of complement activation is the evolutionarily oldest part of this innate immune cascade. It is unique in that it is continuously activated at a low level and arbitrarily probes foreign, modified-self, and also unaltered self-structures. This indiscriminate activation necessitates the presence of preformed regulators on autologous surfaces to spare self-cells from the undirected nature of AP activation. Although the other two canonical complement activation routes, the classical and lectin pathways, initiate the cascade more specifically through pattern recognition, their activity still needs to be tightly controlled to avoid excessive reactivity. It is the perpetual duty of complement regulators to protect the self from damage inflicted by inadequate complement activation. Here, we review the role of complement regulators as preformed mediators of defense, explain their common and specialized functions, and discuss selected cases in which alterations in complement regulators lead to disease. Finally, rational engineering approaches using natural complement inhibitors as potential therapeutics are highlighted. |*Homeostasis [MESH] |*Immunity, Innate [MESH] |Animals [MESH] |Complement Inactivating Agents/therapeutic use [MESH] |Complement System Proteins/*immunology [MESH] |Drug Discovery [MESH] |Humans [MESH] |Immune System Diseases/*immunology/therapy [MESH] |Immunotherapy/*trends [MESH]Protection of host cells by complement regulators (epmc).pdf DeepDyve Pubget Overpricing