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10.1155/2017/2570154 http://scihub22266oqcxt.onion/10.1155/2017/2570154 C5470025!5470025 !28642633     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28642633 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2017 ; 2017 (ä): 2570154 Nephropedia Template TP {{tp|p=28642633 |t=2017. Proteases Revisited: Roles and Therapeutic Implications in Fibrosis |pdf=|usr=}}{{28642633 }} gab.com Text Proteases Revisited: Roles and Therapeutic Implications in Fibrosis JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28642633 #FOAvip Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of cell-cell junctions, release of sequestered growth factors (TGF-? and VEGF), activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility. Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis. Twit Text FOAVip Proteases Revisited: Roles and Therapeutic Implications in Fibrosis ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28642633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28642633 #FOAvip English Wikipedia <ref>{{Cite pmid|28642633 }}</ref> Proteases Revisited: Roles and Therapeutic Implications in Fibrosis #MMPMID28642633 Kryczka J ; Boncela J Mediators Inflamm 2017[]; 2017 (ä): 2570154 PMID28642633 show ga Proteases target many substrates, triggering changes in distinct biological processes correlated with cell migration, EMT/EndMT and fibrosis. Extracellular protease activity, demonstrated by secreted and membrane-bound protease forms, leads to ECM degradation, activation of other proteases (i.e., proteolysis of nonactive zymogens), decomposition of cell-cell junctions, release of sequestered growth factors (TGF-? and VEGF), activation of signal proteins and receptors, degradation of inflammatory inhibitors or inflammation-related proteins, and changes in cell mechanosensing and motility. Intracellular proteases, mainly caspases and cathepsins, modulate lysosome activity and signal transduction pathways. Herein, we discuss the current knowledge on the multidimensional impact of proteases on the development of fibrosis. |Animals [MESH] |Cathepsins/genetics/metabolism [MESH] |Cell Movement/genetics/physiology [MESH] |Fibrosis/*enzymology/genetics [MESH] |Humans [MESH] |Peptide Hydrolases/genetics/*metabolism [MESH] |Protein Binding [MESH] |Signal Transduction [MESH]Proteases Revisited: Roles and Therapeutic Implications in Fibrosis (epmc).pdf DeepDyve Pubget Overpricing