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2015 ; 9
(ä): 157
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Prospects for Optogenetic Augmentation of Brain Function
#MMPMID26635547
Jarvis S
; Schultz SR
Front Syst Neurosci
2015[]; 9
(ä): 157
PMID26635547
show ga
The ability to optically control neural activity opens up possibilities for the
restoration of normal function following neurological disorders. The temporal
precision, spatial resolution, and neuronal specificity that optogenetics offers
is unequalled by other available methods, so will it be suitable for not only
restoring but also extending brain function? As the first demonstrations of
optically "implanted" novel memories emerge, we examine the suitability of
optogenetics as a technique for extending neural function. While optogenetics is
an effective tool for altering neural activity, the largest impediment for
optogenetics in neural augmentation is our systems level understanding of brain
function. Furthermore, a number of clinical limitations currently remain as
substantial hurdles for the applications proposed. While neurotechnologies for
treating brain disorders and interfacing with prosthetics have advanced rapidly
in the past few years, partially addressing some of these critical problems,
optogenetics is not yet suitable for use in humans. Instead we conclude that for
the immediate future, optogenetics is the neurological equivalent of the 3D
printer: its flexibility providing an ideal tool for testing and prototyping
solutions for treating brain disorders and augmenting brain function.