Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/imr.12466 http://scihub22266oqcxt.onion/10.1111/imr.12466 C5096056!5096056 !27782331     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27782331 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27782331 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2016 ; 274 (1 ): 172-190 Nephropedia Template TP {{tp|p=27782331 |t=2016. Properdin: a tightly regulated critical inflammatory modulator |pdf=|usr=}}{{27782331 }} gab.com Text Properdin: a tightly regulated critical inflammatory modulator JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782331 #FOAvip The complement alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory responses in the human host. Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative pathway activity. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. While the formation of non-physiological aggregates in purified properdin preparations and the presence of potential properdin inhibitors in serum have complicated studies of its function, properdin has, regardless, emerged as a key player in various inflammatory disease models. Here, we review basic properdin biology, emphasizing the major hurdles that have complicated the interpretation of results from properdin-centered studies. In addition, we elaborate on an emerging role for properdin in thromboinflammation and discuss the potential utility of properdin inhibitors as long-term therapeutic options to treat diseases marked by increased formation of platelet/granulocyte aggregates. Finally, we describe the interplay between properdin and the alternative pathway negative regulator, Factor H, and how aiming to understand these interactions can provide scientists with the most effective ways to manipulate alternative pathway activation in complex systems. Twit Text FOAVip Properdin: a tightly regulated critical inflammatory modulator ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=27782331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27782331 #FOAvip English Wikipedia <ref>{{Cite pmid|27782331 }}</ref> Properdin: a tightly regulated critical inflammatory modulator #MMPMID27782331 Blatt AZ ; Pathan S ; Ferreira VP Immunol Rev 2016[Nov]; 274 (1 ): 172-190 PMID27782331 show ga The complement alternative pathway is a powerful arm of the innate immune system that enhances diverse inflammatory responses in the human host. Key to the effects of the alternative pathway is properdin, a serum glycoprotein that can both initiate and positively regulate alternative pathway activity. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. While the formation of non-physiological aggregates in purified properdin preparations and the presence of potential properdin inhibitors in serum have complicated studies of its function, properdin has, regardless, emerged as a key player in various inflammatory disease models. Here, we review basic properdin biology, emphasizing the major hurdles that have complicated the interpretation of results from properdin-centered studies. In addition, we elaborate on an emerging role for properdin in thromboinflammation and discuss the potential utility of properdin inhibitors as long-term therapeutic options to treat diseases marked by increased formation of platelet/granulocyte aggregates. Finally, we describe the interplay between properdin and the alternative pathway negative regulator, Factor H, and how aiming to understand these interactions can provide scientists with the most effective ways to manipulate alternative pathway activation in complex systems. |*Complement Pathway, Alternative [MESH] |Animals [MESH] |Complement Factor H/*metabolism [MESH] |Humans [MESH] |Immunomodulation [MESH] |Inflammation/*immunology/therapy [MESH] |Molecular Targeted Therapy [MESH] |Platelet Aggregation [MESH] |Properdin/immunology/*metabolism [MESH]Properdin: a tightly regulated critical inflammatory modulator (epmc).pdf DeepDyve Pubget Overpricing