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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurogastroenterol+Motil
2015 ; 21
(3
): 330-6
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Prokinetics in the Management of Functional Gastrointestinal Disorders
#MMPMID26130629
Quigley EM
J Neurogastroenterol Motil
2015[Jul]; 21
(3
): 330-6
PMID26130629
show ga
A variety of common and some not common gastrointestinal syndromes are thought to
be based on impaired gut motility. For some, the role of motility is well
defined, for others and the functional gastrointestinal disorders, in particular,
the role of hy-po- or dysmotility remains unclear. Over the years pharmacological
and physiological laboratories have developed drugs which stimulate gut motility;
many have been evaluated in motility and functional disorders with what can best
be described as mixed results. Lack of receptor specificity and resultant
expected and unexpected adverse events have led to the demise of some of these
agents. Newer, more selective agents offer promise but the heterogeneity of the
clinical disorders they target continues to pose a formidable challenge to drug
development in this area.