Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25876176
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Hum+Vaccin+Immunother
2015 ; 11
(5
): 1209-22
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Progress on adenovirus-vectored universal influenza vaccines
#MMPMID25876176
Xiang K
; Ying G
; Yan Z
; Shanshan Y
; Lei Z
; Hongjun L
; Maosheng S
Hum Vaccin Immunother
2015[]; 11
(5
): 1209-22
PMID25876176
show ga
Influenza virus (IFV) infection causes serious health problems and heavy
financial burdens each year worldwide. The classical inactivated influenza virus
vaccine (IIVV) and live attenuated influenza vaccine (LAIV) must be updated
regularly to match the new strains that evolve due to antigenic drift and
antigenic shift. However, with the discovery of broadly neutralizing antibodies
that recognize conserved antigens, and the CD8(+) T cell responses targeting
viral internal proteins nucleoprotein (NP), matrix protein 1 (M1) and polymerase
basic 1 (PB1), it is possible to develop a universal influenza vaccine based on
the conserved hemagglutinin (HA) stem, NP, and matrix proteins. Recombinant
adenovirus (rAd) is an ideal influenza vaccine vector because it has an ideal
stability and safety profile, induces balanced humoral and cell-mediated immune
responses due to activation of innate immunity, provides 'self-adjuvanting'
activity, can mimic natural IFV infection, and confers seamless protection
against mucosal pathogens. Moreover, this vector can be developed as a low-cost,
rapid-response vaccine that can be quickly manufactured. Therefore, an adenovirus
vector encoding conserved influenza antigens holds promise in the development of
a universal influenza vaccine. This review will summarize the progress in
adenovirus-vectored universal flu vaccines and discuss future novel approaches.
free
free
free
