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10.1016/j.addr.2017.04.010 http://scihub22266oqcxt.onion/10.1016/j.addr.2017.04.010 C5581987!5581987 !28449873     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28449873 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28449873 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2017 ; 114 (ä): 206-221 Nephropedia Template TP {{tp|p=28449873 |t=2017. Progress in tumor-associated macrophage (TAM)-targeted therapeutics |pdf=|usr=}}{{28449873 }} gab.com Text Progress in tumor-associated macrophage (TAM)-targeted therapeutics JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28449873 #FOAvip As an essential innate immune population for maintaining body homeostasis and warding off foreign pathogens, macrophages display high plasticity and perform diverse supportive functions specialized to different tissue compartments. Consequently, aberrance in macrophage functions contributes substantially to progression of several diseases including cancer, fibrosis, and diabetes. In the context of cancer, tumor-associated macrophages (TAMs) in tumor microenvironment (TME) typically promote cancer cell proliferation, immunosuppression, and angiogenesis in support of tumor growth and metastasis. Oftentimes, the abundance of TAMs in tumor is correlated with poor disease prognosis. Hence, significant attention has been drawn towards development of cancer immunotherapies targeting these TAMs; either depleting them from tumor, blocking their pro-tumoral functions, or restoring their immunostimulatory/tumoricidal properties. This review aims to introduce readers to various aspects in development and evaluation of TAM-targeted therapeutics in pre-clinical and clinical stages. Twit Text FOAVip Progress in tumor-associated macrophage (TAM)-targeted therapeutics ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=28449873 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28449873 #FOAvip English Wikipedia <ref>{{Cite pmid|28449873 }}</ref> Progress in tumor-associated macrophage (TAM)-targeted therapeutics #MMPMID28449873 Ngambenjawong C ; Gustafson HH ; Pun SH Adv Drug Deliv Rev 2017[May]; 114 (ä): 206-221 PMID28449873 show ga As an essential innate immune population for maintaining body homeostasis and warding off foreign pathogens, macrophages display high plasticity and perform diverse supportive functions specialized to different tissue compartments. Consequently, aberrance in macrophage functions contributes substantially to progression of several diseases including cancer, fibrosis, and diabetes. In the context of cancer, tumor-associated macrophages (TAMs) in tumor microenvironment (TME) typically promote cancer cell proliferation, immunosuppression, and angiogenesis in support of tumor growth and metastasis. Oftentimes, the abundance of TAMs in tumor is correlated with poor disease prognosis. Hence, significant attention has been drawn towards development of cancer immunotherapies targeting these TAMs; either depleting them from tumor, blocking their pro-tumoral functions, or restoring their immunostimulatory/tumoricidal properties. This review aims to introduce readers to various aspects in development and evaluation of TAM-targeted therapeutics in pre-clinical and clinical stages. |Animals [MESH] |Humans [MESH] |Immunotherapy/*methods [MESH] |Macrophages/*drug effects/immunology [MESH] |Neoplasms/blood supply/*immunology/pathology/*therapy [MESH]Progress in tumor-associated macrophage (TAM)-targeted therapeutics (epmc).pdf DeepDyve Pubget Overpricing