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2018 ; 31
(5
): 522-531
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Progress in the Management of Primary Aldosteronism
#MMPMID29534182
Morimoto R
; Omata K
; Ito S
; Satoh F
Am J Hypertens
2018[Apr]; 31
(5
): 522-531
PMID29534182
show ga
Primary aldosteronism (PA) is now considered as one of leading causes of
secondary hypertension, accounting for 5-10% of all hypertensive patients and
more strikingly 20% of those with resistant hypertension. Importantly, those with
the unilateral disease could be surgically cured when diagnosed appropriately. On
the other hand, only a very limited portion of those suspected to have PA has
been screened, diagnosed, or treated to date. With current advancement in medical
technologies and genetic research, expanding knowledge of PA has been accumulated
and recent achievements have also been documented in the care of those with PA.
This review is aimed to have focused description on updated topics of the
following; importance of PA screening both in the general and specialized
settings and careful interpretation of screening data, recent achievements in
hormone assays and sampling methods and their clinical relevance, and expanding
knowledge on PA genetics. Improvement in workup processes and novel treatment
options, as well as better understanding of the PA pathogenesis based on genetic
research, might be expected to result in increased cure and better care of the
patients.
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