Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28956025
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28956025
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Anesth+Perioper+Med
2015 ; 2
(4
): 216-225
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Progress in Sympathetically Mediated Pathological Pain
#MMPMID28956025
Chen SS
; Zhang JM
J Anesth Perioper Med
2015[]; 2
(4
): 216-225
PMID28956025
show ga
AIM OF REVIEW: Many chronic pain conditions remain difficult to treat, presenting
a high burden to society. Conditions such as complex regional pain syndrome may
be maintained or exacerbated by sympathetic activity. Understanding the
interactions between sympathetic nervous system and sensory system will help to
improve the effective management of pathological pain including intractable
neuropathic pain and persistent inflammatory pain. METHOD: We first described the
discovery of abnormal connections between sympathetic and sensory neurons.
Subsequently, the functional roles of sympathetic sprouting in altered neuronal
excitability and increased pain sensitivity were discussed. The mechanisms of the
sympathetic sprouting were focusing on its relationship with neurotrophins, local
inflammation, and abnormal spontaneous activity. Finally, we discussed clinical
implications and conflicting findings in the laboratory and clinical research
with respect to the interaction between sympathetic system and sensory system.
RECENT FINDINGS: The findings that sprouting of sympathetic fibers into the
sensory ganglia (dorsal root ganglion) after peripheral nerve injury, offers a
possible explanation of the sympathetic involvement in pain. It is also suggested
that releases of adenosine triphosphate (ATP), in addition to norepinephrine,
from sympathetic nerve endings play important roles in sympathetic-mediated pain.
New evidence indicates the importance of sympathetic innervation in local
inflammatory responses. SUMMARY: Hopefully, this review will reinvigorate the
study of sympathetic-sensory interactions in chronic pain conditions, and help to
better understand how sympathetic system contributes to this serious clinical
problem.