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2011 ; 147
(4
): 742-58
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Programmed cell death in animal development and disease
#MMPMID22078876
Fuchs Y
; Steller H
Cell
2011[Nov]; 147
(4
): 742-58
PMID22078876
show ga
Programmed cell death (PCD) plays a fundamental role in animal development and
tissue homeostasis. Abnormal regulation of this process is associated with a wide
variety of human diseases, including immunological and developmental disorders,
neurodegeneration, and cancer. Here, we provide a brief historical overview of
the field and reflect on the regulation, roles, and modes of PCD during animal
development. We also discuss the function and regulation of apoptotic proteins,
including caspases, the key executioners of apoptosis, and review the nonlethal
functions of these proteins in diverse developmental processes, such as cell
differentiation and tissue remodeling. Finally, we explore a growing body of work
about the connections between apoptosis, stem cells, and cancer, focusing on how
apoptotic cells release a variety of signals to communicate with their cellular
environment, including factors that promote cell division, tissue regeneration,
and wound healing.