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1996 ; 11
(1
): 40-9
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Prognostic factors of patients with thymoma
#MMPMID8882475
Lee WS
; Heo DS
; Bang YJ
; Lee KS
; Ahn JS
; Jung CW
; Han SK
; Sung SW
; Kim JH
; Shim YS
; Park CI
; Kim NK
Korean J Intern Med
1996[Jan]; 11
(1
): 40-9
PMID8882475
show ga
OBJECTIVES: To analyze the prognostic factors influencing the survival of
patients with thymoma, clinical characteristics, treatment modalities and
survival of patients were evaluated. The efficacy of chemotherapy was also
determined. METHODS: Retrospective study was done on one hundred patients whose
diagnosis was confirmed pathologically at Seoul National University Hospital from
1981 to 1994. The staging was carried out according to the Masaoka system.
Survival rate was calculated by the Kaplan-Meier method and prognostic factors
were analyzed by a multivariate analysis (Weibull model). RESULTS: The stage of
100 patients was as follows: Stage I-50, II-6, III-27, IV A-10, IV B-7. The
overall survival rates at 5 and 10 years after diagnosis were 73.1% and 58.7%,
respectively. The 5-year survival differences, according to various prognostic
factors, were as follows: 1) Stage: I-92.8%, II-100%, III-71.6%, IVA-25.9% and
IVB-32.9% (p = 0.0029). 2) Age: < 60 years-79.5% and > or = 60 years-41.5% (p =
0.0489). 3) Extent of resection: Total patients: complete resection-87.6% and
incomplete resection-50.5% (p > 0.05) Stage III: complete resection-66.7% and
incomplete resection-75.5% (p > 0.05) 4) Myasthenia gravis: present-71.6% and
absent-74.9% (p > 0.05) Seventeen patients were treated with a combination
chemotherapy of Cyclophosphamide, Adriamycin and cisplatin(CAP). Two complete
responses and seven partial responses (overall response rate of 53%) were
observed with a median response duration of fourteen months. Combination
chemotherapy with CAP was effective. CONCLUSIONS: Stage and age were the
independent prognostic factors in patients with thymoma. However, the presence of
myasthenia gravis or the extent of resection in stage III patients was not
associated with the survival time.
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