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2017 ; 7
(1
): 4750
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Prognostic cancer gene signatures share common regulatory motifs
#MMPMID28684851
Wang Y
; Goodison S
; Li X
; Hu H
Sci Rep
2017[Jul]; 7
(1
): 4750
PMID28684851
show ga
Scientists have discovered various prognostic gene signatures (GSs) in different
cancer types. Surprisingly, although different GSs from the same cancer type can
be used to measure similar biological characteristics, often rarely is there a
gene shared by different GSs. To explain such a paradox, we hypothesized that GSs
from the same cancer type may be regulated by common regulatory motifs. To test
this hypothesis, we carried out a comprehensive motif analysis on the prognostic
GSs from five cancer types. We demonstrated that GSs from individual cancer type
as well as across cancer types share regulatory motifs. We also observed that
transcription factors that likely bind to these shared motifs have prognostic
functions in cancers. Moreover, 75% of the predicted cofactors of these
transcription factors may have cancer-related functions and some cofactors even
have prognostic functions. In addition, there exist common microRNAs that
regulate different GSs from individual cancer types and across cancer types,
several of which are prognostic biomarkers for the corresponding cancer types.
Our study suggested the existence of common regulatory mechanisms shared by GSs
from individual cancer types and across cancer types, which shed light on the
discovery of new prognostic GSs in cancers and the understanding of the
regulatory mechanisms of cancers.
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