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2015 ; 52
(9
): 5393-407
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Prodigiosin and its potential applications
#MMPMID26344956
Darshan N
; Manonmani HK
J Food Sci Technol
2015[Sep]; 52
(9
): 5393-407
PMID26344956
show ga
Since a decade, there has been a strong consumer demand for more natural
products. This has augmented inclination towards substitution of synthetic
colorants with natural pigments. Natural pigments not only have the capacity to
increase the marketability of products, they also demonstrate valuable biological
activities as antioxidants and anticancer agents. There is a long history of
exploitation of natural products produced by bacteria as sources of
pharmaceutically important, bioactive compounds. Among natural pigments, pigments
from microbial sources are potentially suitable alternatives to synthetic
pigments. The red pigment prodigiosin (PG) has unusual properties, which have
long been documented. The red-pigmented prodiginines are bioactive secondary
metabolites produced by both Gram-negative and Gram-positive bacteria.
Prodigiosins are characterized by a common pyrrolyl pyrromethene skeleton, and
the biological role of these pigments in the producer organisms remains unclear.
Bacterial prodigiosins and their synthetic derivatives are effective proapoptotic
agents against various cancer cell lines, with multiple cellular targets
including multi-drug resistant cells with little or no toxicity towards normal
cell lines. However, research into the biology of pigment production will
stimulate interest in the bioengineering of strains to synthesize useful
prodiginine derivatives. This review article highlights the characteristics and
potential applications of prodigiosin pigment from Serratia as prodigiosins are
real potential therapeutic drugs.