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10.1371/journal.pgen.1006700 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1006700 C5393890!5393890 !28369070     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28369070 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28369070 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Genet 2017 ; 13 (4 ): e1006700 Nephropedia Template TP {{tp|p=28369070 |t=2017. Probing the canonicity of the Wnt/Wingless signaling pathway |pdf=|usr=}}{{28369070 }} gab.com Text Probing the canonicity of the Wnt/Wingless signaling pathway JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=28369070 #FOAvip The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes by the beta-catenin/TCF complex. Several studies have proposed alternative interaction partners for beta-catenin or TCF, but the relevance of potential bifurcations in the distal Wnt pathway remains unclear. Here we study on a genome-wide scale the requirement for Armadillo (Arm, Drosophila beta-catenin) and Pangolin (Pan, Drosophila TCF) in the Wnt/Wingless(Wg)-induced transcriptional response of Drosophila Kc cells. Using somatic genetics, we demonstrate that both Arm and Pan are absolutely required for mediating activation and repression of target genes. Furthermore, by means of STARR-sequencing we identified Wnt/Wg-responsive enhancer elements and found that all responsive enhancers depend on Pan. Together, our results confirm the dogma of canonical Wnt/Wg signaling and argue against the existence of distal pathway branches in this system. Twit Text FOAVip Probing the canonicity of the Wnt/Wingless signaling pathway ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=28369070 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28369070 #FOAvip English Wikipedia <ref>{{Cite pmid|28369070 }}</ref> Probing the canonicity of the Wnt/Wingless signaling pathway #MMPMID28369070 Franz A ; Shlyueva D ; Brunner E ; Stark A ; Basler K PLoS Genet 2017[Apr]; 13 (4 ): e1006700 PMID28369070 show ga The hallmark of canonical Wnt signaling is the transcriptional induction of Wnt target genes by the beta-catenin/TCF complex. Several studies have proposed alternative interaction partners for beta-catenin or TCF, but the relevance of potential bifurcations in the distal Wnt pathway remains unclear. Here we study on a genome-wide scale the requirement for Armadillo (Arm, Drosophila beta-catenin) and Pangolin (Pan, Drosophila TCF) in the Wnt/Wingless(Wg)-induced transcriptional response of Drosophila Kc cells. Using somatic genetics, we demonstrate that both Arm and Pan are absolutely required for mediating activation and repression of target genes. Furthermore, by means of STARR-sequencing we identified Wnt/Wg-responsive enhancer elements and found that all responsive enhancers depend on Pan. Together, our results confirm the dogma of canonical Wnt/Wg signaling and argue against the existence of distal pathway branches in this system. |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Armadillo Domain Proteins/genetics/*metabolism [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster/genetics/*metabolism [MESH] |Enhancer Elements, Genetic [MESH] |Gene Expression Regulation [MESH] |Genome, Insect [MESH] |Repressor Proteins/genetics/*metabolism [MESH] |Sequence Analysis, RNA [MESH] |Signal Transduction [MESH] |Transcription Factors/genetics/*metabolism [MESH]Probing the canonicity of the Wnt/Wingless signaling pathway (epmc).pdf DeepDyve Pubget Overpricing