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Proapoptotic Role of Potassium Ions in Liver Cells
#MMPMID27069917
Xia Z
; Huang X
; Chen K
; Wang H
; Xiao J
; He K
; Huang R
; Duan X
; Liu H
; Zhang J
; Xiang G
Biomed Res Int
2016[]; 2016
(?): 1729135
PMID27069917
show ga
Potassium channels are transmembrane proteins that selectively promote the
infiltration of potassium ions. The significance of these channels for tumor
biology has become obvious. However, the effects of potassium ions on the tumor
or normal cells have seldom been studied. To address this problem, we studied the
biological effects of L02 and HepG2 cells with ectogenous potassium ions. Cell
proliferation, cell cycle, and apoptosis rate were analyzed. Our results
indicated that potassium ions inhibited proliferation of L02 and HepG2 cells and
promoted their apoptosis. Potassium ions induced apoptosis through regulating
Bcl-2 family members and depolarized the mitochondrial membrane, especially for
HepG2 cell. These biological effects were associated with channel protein HERG.
By facilitating expression of channel protein HERG, potassium ions may prevent it
from being shunted to procancerous pathways by inducing apoptosis. These results
demonstrated that potassium ions may be a key regulator of liver cell function.
Thus, our findings suggest that potassium ions could inhibit tumorigenesis
through inducing apoptosis of hepatoma cells by upregulating potassium ions
transport channel proteins HERG and VDAC1.
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