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10.1016/j.it.2014.10.003 http://scihub22266oqcxt.onion/10.1016/j.it.2014.10.003 C4429004!4429004 !25457352     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25457352 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Immunol 2014 ; 35 (12 ): 622-630 Nephropedia Template TP {{tp|p=25457352 |t=2014. Prion-like polymerization as a signaling mechanism |pdf=|usr=}}{{25457352 }} gab.com Text Prion-like polymerization as a signaling mechanism JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25457352 #FOAvip The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to sense pathogen invasion and other danger signals. Activation of these receptors induces robust signal transduction cascades that trigger the production of cytokines important for host protection. MAVS and ASC are essential adaptor proteins downstream of RIG-I and NLRP3, respectively, and both contain N-terminal domains belonging to the death domain superfamily. Recent studies suggest that both MAVS and ASC form functional prion-like fibers through their respective death domains to propagate downstream signaling. Here, we review these findings, and in this context discuss the emerging concept of prion-like polymerization in signal transduction. We further examine the potential benefits of this signaling strategy, including signal amplification, host evolutionary advantage, and molecular memory. Twit Text FOAVip Prion-like polymerization as a signaling mechanism ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25457352 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25457352 #FOAvip English Wikipedia <ref>{{Cite pmid|25457352 }}</ref> Prion-like polymerization as a signaling mechanism #MMPMID25457352 Cai X ; Chen ZJ Trends Immunol 2014[Dec]; 35 (12 ): 622-630 PMID25457352 show ga The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to sense pathogen invasion and other danger signals. Activation of these receptors induces robust signal transduction cascades that trigger the production of cytokines important for host protection. MAVS and ASC are essential adaptor proteins downstream of RIG-I and NLRP3, respectively, and both contain N-terminal domains belonging to the death domain superfamily. Recent studies suggest that both MAVS and ASC form functional prion-like fibers through their respective death domains to propagate downstream signaling. Here, we review these findings, and in this context discuss the emerging concept of prion-like polymerization in signal transduction. We further examine the potential benefits of this signaling strategy, including signal amplification, host evolutionary advantage, and molecular memory. äPrion-like polymerization as a signaling mechanism (epmc).pdf DeepDyve Pubget Overpricing