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2018 ; 7
(1
): ä Nephropedia Template TP
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Prion Strains and Transmission Barrier Phenomena
#MMPMID29301257
Igel-Egalon A
; Béringue V
; Rezaei H
; Sibille P
Pathogens
2018[Jan]; 7
(1
): ä PMID29301257
show ga
Several experimental evidences show that prions are non-conventional pathogens,
which physical support consists only in proteins. This finding raised questions
regarding the observed prion strain-to-strain variations and the species barrier
that happened to be crossed with dramatic consequences on human health and
veterinary policies during the last 3 decades. This review presents a focus on a
few advances in the field of prion structure and prion strains characterization:
from the historical approaches that allowed the concept of prion strains to
emerge, to the last results demonstrating that a prion strain may in fact be a
combination of a few quasi species with subtle biophysical specificities. Then,
we will focus on the current knowledge on the factors that impact species barrier
strength and species barrier crossing. Finally, we present probable scenarios on
how the interaction of strain properties with host characteristics may account
for differential selection of new conformer variants and eventually species
barrier crossing.
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