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2015 ; 26
(9-10
): 467-81
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Principles and application of LIMS in mouse clinics
#MMPMID26208973
Maier H
; Schütt C
; Steinkamp R
; Hurt A
; Schneltzer E
; Gormanns P
; Lengger C
; Griffiths M
; Melvin D
; Agrawal N
; Alcantara R
; Evans A
; Gannon D
; Holroyd S
; Kipp C
; Raj NP
; Richardson D
; LeBlanc S
; Vasseur L
; Masuya H
; Kobayashi K
; Suzuki T
; Tanaka N
; Wakana S
; Walling A
; Clary D
; Gallegos J
; Fuchs H
; de Angelis MH
; Gailus-Durner V
Mamm Genome
2015[Oct]; 26
(9-10
): 467-81
PMID26208973
show ga
Large-scale systemic mouse phenotyping, as performed by mouse clinics for more
than a decade, requires thousands of mice from a multitude of different mutant
lines to be bred, individually tracked and subjected to phenotyping procedures
according to a standardised schedule. All these efforts are typically organised
in overlapping projects, running in parallel. In terms of logistics, data
capture, data analysis, result visualisation and reporting, new challenges have
emerged from such projects. These challenges could hardly be met with traditional
methods such as pen & paper colony management, spreadsheet-based data management
and manual data analysis. Hence, different Laboratory Information Management
Systems (LIMS) have been developed in mouse clinics to facilitate or even enable
mouse and data management in the described order of magnitude. This review shows
that general principles of LIMS can be empirically deduced from LIMS used by
different mouse clinics, although these have evolved differently. Supported by
LIMS descriptions and lessons learned from seven mouse clinics, this review also
shows that the unique LIMS environment in a particular facility strongly
influences strategic LIMS decisions and LIMS development. As a major conclusion,
this review states that there is no universal LIMS for the mouse research domain
that fits all requirements. Still, empirically deduced general LIMS principles
can serve as a master decision support template, which is provided as a hands-on
tool for mouse research facilities looking for a LIMS.
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