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2013 ; 3
(9
): a015503
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Primate models in organ transplantation
#MMPMID24003248
Anderson DJ
; Kirk AD
Cold Spring Harb Perspect Med
2013[Sep]; 3
(9
): a015503
PMID24003248
show ga
Large animal models have long served as the proving grounds for advances in
transplantation, bridging the gap between inbred mouse experimentation and human
clinical trials. Although a variety of species have been and continue to be used,
the emergence of highly targeted biologic- and antibody-based therapies has
required models to have a high degree of homology with humans. Thus, the nonhuman
primate has become the model of choice in many settings. This article will
provide an overview of nonhuman primate models of transplantation. Issues of
primate genetics and care will be introduced, and a brief overview of technical
aspects for various transplant models will be discussed. Finally, several
prominent immunosuppressive and tolerance strategies used in primates will be
reviewed.