Primate autoimmune disease models; lost for translation?
#MMPMID28435673
't Hart BA
Clin Transl Immunology
2016[Dec]; 5
(12
): e122
PMID28435673
show ga
Replacement, reduction and refinement (the 3R's) are the leading principles in
translational research with animals. To be useful a model should also be
clinically Relevant (the 4th R). Work in a non-human primate model of multiple
sclerosis, the experimental autoimmune encephalomyelitis model, reveals an
inherent conflict among these 4R principles. The impossibility to harmonize all
4R's forms a major challenge when the model is applied in preclinical drug
development.
