Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24864023
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24864023
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Birth+Defects+Res+C+Embryo+Today
2014 ; 102
(2
): 139-58
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Primary cilia in pancreatic development and disease
#MMPMID24864023
Lodh S
; O'Hare EA
; Zaghloul NA
Birth Defects Res C Embryo Today
2014[Jun]; 102
(2
): 139-58
PMID24864023
show ga
Primary cilia and their anchoring basal bodies are important regulators of a
growing list of signaling pathways. Consequently, dysfunction in proteins
associated with these structures results in perturbation of the development and
function of a spectrum of tissue and cell types. Here, we review the role of
cilia in mediating the development and function of the pancreas. We focus on
ciliary regulation of major pathways involved in pancreatic development,
including Shh, Wnt, TGF-?, Notch, and fibroblast growth factor. We also discuss
pancreatic phenotypes associated with ciliary dysfunction, including pancreatic
cysts and defects in glucose homeostasis, and explore the potential role of cilia
in such defects.
free
free
free
