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2015 ; 2015
(ä): 514159
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Prevention of Ovarian Hyperstimulation Syndrome: A Review
#MMPMID26074966
Smith V
; Osianlis T
; Vollenhoven B
Obstet Gynecol Int
2015[]; 2015
(ä): 514159
PMID26074966
show ga
The following review aims to examine the available evidence to guide best
practice in preventing ovarian hyperstimulation syndrome (OHSS). As it stands,
there is no single method to completely prevent OHSS. There seems to be a
benefit, however, in categorizing women based on their risk of OHSS and
individualizing treatments to curtail their chances of developing the syndrome.
At present, both Anti-Müllerian Hormone and the antral follicle count seem to be
promising in this regard. Both available and upcoming therapies are also reviewed
to give a broad perspective to clinicians with regard to management options. At
present, we recommend the use of a "step-up" regimen for ovulation induction,
adjunct metformin utilization, utilizing a GnRH agonist as an ovulation trigger,
and cabergoline usage. A summary of recommendations is also made available for
ease of clinical application. In addition, areas for potential research are also
identified where relevant.