Prevention and treatment of the post-thrombotic syndrome
#MMPMID30046723
Ten Cate-Hoek AJ
Res Pract Thromb Haemost
2018[Apr]; 2
(2
): 209-219
PMID30046723
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Post thrombotic syndrome (PTS) is a common chronic complication of deep vein
thrombosis of the leg (DVT). Treatment options are limited therefore emphasis is
placed on its prevention. Several risk factors have been recognized, but were so
far not used for risk stratification or translation into prediction models. Early
interventions did not yet result in more successful preventive treatment
strategies; for the acute phase of DVT there is equipoise on the value of elastic
compression, as well as on catheter directed thrombolysis. There are no drugs
specifically targeted at PTS prevention. The use of anticoagulant medication such
as direct oral anticoagulants (DOACs) might decrease PTS incidence, but this
needs to be corroborated. Both research into more effective treatment options as
well as future PTS management may benefit from a uniform diagnostic strategy and
the use of prediction rules to better allocate treatment and thereby increase
treatment efficacy.
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