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Prevention and Management of Chronic Hepatitis B
#MMPMID26622990
Bhat M
; Ghali P
; Deschenes M
; Wong P
Int J Prev Med
2014[Dec]; 5
(Suppl 3
): S200-7
PMID26622990
show ga
Chronic hepatitis B virus (HBV) infection affects an estimated 370 million people
worldwide. HBV is endemic throughout the world, and insidiously causes liver
damage over years and decades without any warning symptoms or signs. Up to 25-35%
of infected individuals eventually die due to complications of liver cirrhosis
and hepatocellular carcinoma (HCC) induced by HBV. Screening those individuals at
risk of acquiring hepatitis B, and universal vaccination for prevention, would
help in limiting the spread and public health repercussions of the virus.
Although many new antiviral therapies have been developed for the management of
hepatitis B, they still do not offer the possibility of cure. Most individuals
who begin oral suppressive therapy will be indefinitely treated. Continuous
suppression of HBV replication in individuals with advanced liver disease
prolongs life, decreases the need for liver transplantation, and potentially
reduces the risk for HCC. In this clinical review, we present a practical
approach to prevention of HBV, its natural history and life cycle, as well as its
management.
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