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10.1016/j.celrep.2015.09.036 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.09.036 C4626381!4626381 !26489460     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26489460 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26489460 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2015 ; 13 (4 ): 760-770 Nephropedia Template TP {{tp|p=26489460 |t=2015. Preventing Allograft Rejection by Targeting Immune Metabolism |pdf=|usr=}}{{26489460 }} gab.com Text Preventing Allograft Rejection by Targeting Immune Metabolism JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26489460 #FOAvip Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition. Although such metabolic reprogramming promotes the differentiation and function of T effector cells, the differentiation of regulatory T cells employs different metabolic reprogramming. Therefore, we hypothesized that inhibition of glycolysis and glutamine metabolism might prevent graft rejection by inhibiting effector generation and function and promoting regulatory T cell generation. We devised an anti-rejection regimen involving the glycolytic inhibitor 2-deoxyglucose (2-DG), the anti-type II diabetes drug metformin, and the inhibitor of glutamine metabolism 6-diazo-5-oxo-L-norleucine (DON). Using this triple-drug regimen, we were able to prevent or delay graft rejection in fully mismatched skin and heart allograft transplantation models. Twit Text FOAVip Preventing Allograft Rejection by Targeting Immune Metabolism ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26489460 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26489460 #FOAvip English Wikipedia <ref>{{Cite pmid|26489460 }}</ref> Preventing Allograft Rejection by Targeting Immune Metabolism #MMPMID26489460 Lee CF ; Lo YC ; Cheng CH ; Furtmüller GJ ; Oh B ; Andrade-Oliveira V ; Thomas AG ; Bowman CE ; Slusher BS ; Wolfgang MJ ; Brandacher G ; Powell JD Cell Rep 2015[Oct]; 13 (4 ): 760-770 PMID26489460 show ga Upon antigen recognition and co-stimulation, T lymphocytes upregulate the metabolic machinery necessary to proliferate and sustain effector function. This metabolic reprogramming in T cells regulates T cell activation and differentiation but is not just a consequence of antigen recognition. Although such metabolic reprogramming promotes the differentiation and function of T effector cells, the differentiation of regulatory T cells employs different metabolic reprogramming. Therefore, we hypothesized that inhibition of glycolysis and glutamine metabolism might prevent graft rejection by inhibiting effector generation and function and promoting regulatory T cell generation. We devised an anti-rejection regimen involving the glycolytic inhibitor 2-deoxyglucose (2-DG), the anti-type II diabetes drug metformin, and the inhibitor of glutamine metabolism 6-diazo-5-oxo-L-norleucine (DON). Using this triple-drug regimen, we were able to prevent or delay graft rejection in fully mismatched skin and heart allograft transplantation models. |Allografts [MESH] |Animals [MESH] |CD8-Positive T-Lymphocytes/drug effects/metabolism [MESH] |Cells, Cultured [MESH] |Deoxyglucose/therapeutic use [MESH] |Diazooxonorleucine/therapeutic use [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Flow Cytometry [MESH] |Glutamine/metabolism [MESH] |Glycolysis/drug effects/physiology [MESH] |Graft Rejection/*prevention & control [MESH] |Heart Transplantation/methods [MESH] |Metformin/therapeutic use [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Transgenic [MESH] |Phosphorylation/drug effects/physiology [MESH]Preventing Allograft Rejection by Targeting Immune Metabolism (epmc).pdf DeepDyve Pubget Overpricing