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2017 ; 30
(3
): 403-409
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Prevalence of chronic kidney disease after preeclampsia
#MMPMID27491315
Lopes van Balen VA
; Spaan JJ
; Cornelis T
; Spaanderman MEA
J Nephrol
2017[Jun]; 30
(3
): 403-409
PMID27491315
show ga
BACKGROUND: Preeclampsia (PE), an endothelial disease that affects kidney
function during pregnancy, is correlated to an increased future risk of
cardiovascular and chronic kidney disease. The Kidney Disease Improving Global
Outcomes (KDIGO) 2012 guideline emphasizes the combined role of glomerular
filtration rate (GFR) and albuminuria in determining the frequency of monitoring
of kidney function. OBJECTIVES: In this study we evaluated the prevalence of CKD
in women with a history of PE. We investigated how many seemingly healthy women
required monitoring of kidney function according to the KDIGO guideline. METHODS:
We included 775 primiparous women with a history of PE. They were at least
4 months postpartum, and had no pre-existing hypertension, diabetes or kidney
disease. We estimated GFR by the CKD-Epidemiology equation and urinary albumin
loss by albumin creatinine ratio in a 24-h urine collection. RESULTS: Most women,
669 (86.3 %), had a normal GFR and absent albuminuria. Based on the KDIGO
guideline, 13.7 % would require at least yearly monitoring of kidney function.
Only 1.4 % were classified to be at high risk for kidney function deterioration.
CONCLUSION: Monitoring of kidney function seems relevant for about one in seven
women with a history of PE, mainly due to albuminuria. Albuminuria should be
evaluated postpartum to identify those women that need further monitoring of
kidney function.
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