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2016 ; 7
(2
): 115-20
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Prevalence and clinical profile of fungal rhinosinusitis
#MMPMID27349695
Suresh S
; Arumugam D
; Zacharias G
; Palaninathan S
; Vishwanathan R
; Venkatraman V
Allergy Rhinol (Providence)
2016[Jan]; 7
(2
): 115-20
PMID27349695
show ga
BACKGROUND: There are only a few landmark studies from the Indian subcontinent on
fungal rhinosinusitis. The lack of awareness among clinicians regarding the
varying clinical presentations of fungal rhinosinusitis prompted us to undertake
this study. OBJECTIVE: To determine the prevalence, etiologic basis, clinical
features, radiologic features, and microscopic features of fungal rhinosinusitis,
and to evaluate the various treatment modalities available. METHODS: This was a
prospective study in which evaluation of 100 patients with chronic rhinosinusitis
was done. Specimens collected were subjected to both microbiology and pathologic
examination; data collected, including clinical and radiologic features, were
analyzed by the Pearson ?(2) test and Fisher's exact test. RESULTS: The
prevalence of fungal rhinosinusitis in our study was 30% (n = 30). Mucor was the
most commonly isolated species (n = 15 [50%]) of fungus. Pathologic examination
had a higher sensitivity (76.67%) compared with microbiology tests (50%) in the
diagnosis of fungal rhinosinusitis. Fungus ball (n = 14 [46.6%]) was the most
prevalent entity in the spectrum of fungal rhinosinusitis. Forty percent of cases
(n = 12) were of invasive fungal rhinosinusitis. The prevalence of fungal
rhinosinusitis was higher among individuals who were immunocompetent (n = 17
[56.6%]). Of patients who were immunocompromised, 84.6% (n = 11) had
mucormycosis. CONCLUSIONS: Unilateral involvement of paranasal sinuses was more
in favor of fungal etiology. Complications were more common in fungal
rhinosinusitis caused by Mucor species. Mucormycosis, a rare clinical entity, in
subjects who were immunocompetent, had a high prevalence in our study.