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2014 ; 37
(10
): 572-82
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Preserve and protect: maintaining axons within functional circuits
#MMPMID25167775
Pease SE
; Segal RA
Trends Neurosci
2014[Oct]; 37
(10
): 572-82
PMID25167775
show ga
During development, neural circuits are initially generated by exuberant
innervation and are rapidly refined by selective preservation and elimination of
axons. The establishment and maintenance of functional circuits therefore
requires coordination of axon survival and degeneration pathways. Both developing
and mature circuits rely on interdependent mitochondrial and cytoskeletal
components to maintain axonal health and homeostasis; injury or diseases that
impinge on these components frequently cause pathologic axon loss. Here, we
review recent findings that identify mechanisms of axonal preservation in the
contexts of development, injury, and disease.