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10.1016/j.tins.2014.07.007

http://scihub22266oqcxt.onion/10.1016/j.tins.2014.07.007
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suck abstract from ncbi


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pmid25167775
      Trends+Neurosci 2014 ; 37 (10 ): 572-82
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  • Preserve and protect: maintaining axons within functional circuits #MMPMID25167775
  • Pease SE ; Segal RA
  • Trends Neurosci 2014[Oct]; 37 (10 ): 572-82 PMID25167775 show ga
  • During development, neural circuits are initially generated by exuberant innervation and are rapidly refined by selective preservation and elimination of axons. The establishment and maintenance of functional circuits therefore requires coordination of axon survival and degeneration pathways. Both developing and mature circuits rely on interdependent mitochondrial and cytoskeletal components to maintain axonal health and homeostasis; injury or diseases that impinge on these components frequently cause pathologic axon loss. Here, we review recent findings that identify mechanisms of axonal preservation in the contexts of development, injury, and disease.
  • |Animals [MESH]
  • |Axons/pathology/*physiology [MESH]
  • |Cytoskeleton/metabolism/pathology/*physiology [MESH]
  • |Mitochondria/metabolism/*physiology [MESH]
  • |Neural Pathways/growth & development/pathology/*physiology [MESH]
  • |Signal Transduction/*physiology [MESH]


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