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10.1038/cmi.2015.109 http://scihub22266oqcxt.onion/10.1038/cmi.2015.109 C4856799!4856799 !26924525     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26924525 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Mol+Immunol 2016 ; 13 (3 ): 293-300 Nephropedia Template TP {{tp|p=26924525 |t=2016. Presentation of hepatocellular antigens |pdf=|usr=}}{{26924525 }} gab.com Text Presentation of hepatocellular antigens JO: Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26924525 #FOAvip The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general. These include tolerance toward antigens introduced via the portal vein, immune failure to several hepatotropic viruses, the lack of natural liver-stage immunity to malaria parasites, and the frequent metastasis of cancers to the liver. Here we review the mechanisms by which T cells engage with hepatocellular antigens, the context in which such encounters occur, and the mechanisms that act to suppress a full T-cell response. While many mechanisms play a role, we will argue that two important processes are the constraints on the cross-presentation of hepatocellular antigens, and the induction of negative feedback inhibition driven by interferons. The constant exposure of the liver to microbial products from the intestine may drive innate immunity, rendering the local environment unfavorable for specific T-cell responses through this mechanism. Nevertheless, tolerance toward hepatocellular antigens is not monolithic and under specific circumstances allows both effective immunity and immunopathology. Twit Text FOAVip Presentation of hepatocellular antigens ????Cell Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26924525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26924525 #FOAvip English Wikipedia <ref>{{Cite pmid|26924525 }}</ref> Presentation of hepatocellular antigens #MMPMID26924525 Grakoui A ; Crispe IN Cell Mol Immunol 2016[May]; 13 (3 ): 293-300 PMID26924525 show ga The liver is an organ in which antigen-specific T-cell responses manifest a bias toward immune tolerance. This is clearly seen in the rejection of allogeneic liver transplants, and multiple other phenomena suggest that this effect is more general. These include tolerance toward antigens introduced via the portal vein, immune failure to several hepatotropic viruses, the lack of natural liver-stage immunity to malaria parasites, and the frequent metastasis of cancers to the liver. Here we review the mechanisms by which T cells engage with hepatocellular antigens, the context in which such encounters occur, and the mechanisms that act to suppress a full T-cell response. While many mechanisms play a role, we will argue that two important processes are the constraints on the cross-presentation of hepatocellular antigens, and the induction of negative feedback inhibition driven by interferons. The constant exposure of the liver to microbial products from the intestine may drive innate immunity, rendering the local environment unfavorable for specific T-cell responses through this mechanism. Nevertheless, tolerance toward hepatocellular antigens is not monolithic and under specific circumstances allows both effective immunity and immunopathology. |Animals [MESH] |Antigen Presentation/*immunology [MESH] |Antigen-Presenting Cells/immunology [MESH] |Hepatocytes/*immunology/pathology [MESH] |Humans [MESH] |Immune Tolerance [MESH] |Inflammation/pathology [MESH]Presentation of hepatocellular antigens (epmc).pdf DeepDyve Pubget Overpricing