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2016 ; 21
(2
): 95-101
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Present status of Accelerator-Based BNCT
#MMPMID26933390
Kreiner AJ
; Bergueiro J
; Cartelli D
; Baldo M
; Castell W
; Asoia JG
; Padulo J
; Suárez Sandín JC
; Igarzabal M
; Erhardt J
; Mercuri D
; Valda AA
; Minsky DM
; Debray ME
; Somacal HR
; Capoulat ME
; Herrera MS
; Del Grosso MF
; Gagetti L
; Anzorena MS
; Canepa N
; Real N
; Gun M
; Tacca H
Rep Pract Oncol Radiother
2016[Mar]; 21
(2
): 95-101
PMID26933390
show ga
AIM: This work aims at giving an updated report of the worldwide status of
Accelerator-Based BNCT (AB-BNCT). BACKGROUND: There is a generalized perception
that the availability of accelerators installed in hospitals, as neutron sources,
may be crucial for the advancement of BNCT. Accordingly, in recent years a
significant effort has started to develop such machines. MATERIALS AND METHODS: A
variety of possible charged-particle induced nuclear reactions and the
characteristics of the resulting neutron spectra are discussed along with the
worldwide activity in suitable accelerator development. RESULTS: Endothermic
(7)Li(p,n)(7)Be and (9)Be(p,n)(9)B and exothermic (9)Be(d,n)(10)B are compared.
In addition to having much better thermo-mechanical properties than Li, Be as a
target leads to stable products. This is a significant advantage for a
hospital-based facility. (9)Be(p,n)(9)B needs at least 4-5 MeV bombarding energy
to have a sufficient yield, while (9)Be(d,n)(10)B can be utilized at about
1.4 MeV, implying the smallest possible accelerator. This reaction operating with
a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT.
The machines considered are electrostatic single ended or tandem accelerators or
radiofrequency quadrupoles plus drift tube Linacs. CONCLUSIONS: (7)Li(p,n)(7)Be
provides one of the best solutions for the production of epithermal neutron beams
for deep-seated tumors. However, a Li-based target poses significant
technological challenges. Hence, Be has been considered as an alternative target,
both in combination with (p,n) and (d,n) reactions. (9)Be(d,n)(10)B at 1.4 MeV,
with a thin target has been shown to be a realistic option for the treatment of
deep-seated lesions.
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