Prenatal Screening Using Maternal Markers
#MMPMID26237388
Cuckle H
J Clin Med
2014[May]; 3
(2
): 504-20
PMID26237388
show ga
Maternal markers are widely used to screen for fetal neural tube defects (NTDs),
chromosomal abnormalities and cardiac defects. Some are beginning to broaden
prenatal screening to include pregnancy complications such as pre-eclampsia. The
methods initially developed for NTDs using a single marker have since been built
upon to develop high performance multi-maker tests for chromosomal abnormalities.
Although cell-free DNA testing is still too expensive to be considered for
routine application in public health settings, it can be cost-effective when used
in combination with existing multi-maker marker tests. The established screening
methods can be readily applied in the first trimester to identify pregnancies at
high risk of pre-eclampsia and offer prevention though aspirin treatment.
Prenatal screening for fragile X syndrome might be adopted more widely if the
test was to be framed as a form of maternal marker screening.
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