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2015 ; 39
(2 Pt A
): 59-66
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Premature Atherosclerotic Cardiovascular Disease in Childhood Cancer Survivors
#MMPMID26823646
Shepard CW
; Steinberger J
Prog Pediatr Cardiol
2015[Nov]; 39
(2 Pt A
): 59-66
PMID26823646
show ga
Survival rates of childhood cancer have increased over the last 30 years,
revealing a population with unique characteristics and risks. The effects of
radiation and cardiotoxic chemotherapy predispose these children to both early
and late cardiovascular disease. Cranial radiation also increases the likelihood
of growth hormone deficiency, which leads to metabolic disturbances. Childhood
cancer survivors are less likely to be active than their healthy siblings, and
have a lower aptitude for physical activity. These issues are additive to the
usual risks experienced by the general population, thereby significantly
increasing the likelihood of premature cardiovascular disease. Early and regular
screening and risk factor management in this population is recommended.