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Precision Light for the Treatment of Psychiatric Disorders
#MMPMID29593784
Kaladchibachi S
; Fernandez F
Neural Plast
2018[]; 2018
(?): 5868570
PMID29593784
show ga
Circadian timekeeping can be reset by brief flashes of light using stimulation
protocols thousands of times shorter than those previously assumed to be
necessary for traditional phototherapy. These observations point to a future
where flexible architectures of nanosecond-, microsecond-, and millisecond-scale
light pulses are compiled to reprogram the brain's internal clock when it has
been altered by psychiatric illness or advanced age. In the current review, we
present a chronology of seminal experiments that established the synchronizing
influence of light on the human circadian system and the efficacy of prolonged
bright-light exposure for reducing symptoms associated with seasonal affective
disorder. We conclude with a discussion of the different ways that precision
flashes could be parlayed during sleep to effect neuroadaptive changes in brain
function. This article is a contribution to a special issue on Circadian Rhythms
in Regulation of Brain Processes and Role in Psychiatric Disorders curated by
editors Shimon Amir, Karen Gamble, Oliver Stork, and Harry Pantazopoulos.
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