Practical considerations for the use of mTOR inhibitors
#MMPMID27293552
Diekmann F
; Campistol JM
Transplant Res
2015[]; 4
(Suppl 1
): 5
PMID27293552
show ga
Immunosuppressive therapy after kidney transplantation is based on calcineurin
inhibitors (CNI). In most cases CNI therapy is combined with mycophenolate and
steroids. In spite of good short-term results this therapy is associated with
long-term toxicities, graft loss and patient death. Therefore, alternative
immunosuppressive strategies are needed that combine excellent efficacy with low
incidences of long-term adverse outcomes. This review focuses on the strategies
based on mTOR- inhibitors in combination with minimized exposure to CNI.