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2020 ; 14
(ä): 1753466620926853
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Potential specific therapies in COVID-19
#MMPMID32436445
Gul MH
; Htun ZM
; Shaukat N
; Imran M
; Khan A
Ther Adv Respir Dis
2020[Jan]; 14
(ä): 1753466620926853
PMID32436445
show ga
COVID-19 has grown into a global pandemic that has strained healthcare throughout
the world. There is a sense of urgency in finding a cure for this deadly virus.
In this study, we reviewed the empiric options used in common practice for
COVID-19, based on the literature available online, with an emphasis on human
experiences with these treatments on severe acute respiratory syndrome-associated
coronavirus (SARS-COV-1) and other viruses. Convalescent blood products are the
most promising potential treatment for use in COVID-19. The use of chloroquine or
hydroxychloroquine (HCQ), remdesivir, and tocilizumab are some of the other
promising potential therapies; however, they are yet to be tested in randomized
clinical trials (RCTs). The use of lopinavir-ritonavir did not prove beneficial
in a large RCT. The use of corticosteroids should be avoided in COVID-19
pneumonia unless used for other indications, based on the suggestion of harm in
patients with SARS-COV-1 and Middle Eastern Respiratory Syndrome (MERS)
infection. The reviews of this paper are available via the supplemental material
section.
|Antiviral Agents/adverse effects/therapeutic use
[MESH]