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10.1007/s10237-012-0417-4 http://scihub22266oqcxt.onion/10.1007/s10237-012-0417-4 C3526694!3526694 !22782543     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22782543 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\22782543 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomech+Model+Mechanobiol 2013 ; 12 (3 ): 467-74 Nephropedia Template TP {{tp|p=22782543 |t=2013. Potential fluid mechanic pathways of platelet activation |pdf=|usr=}}{{22782543 }} gab.com Text Potential fluid mechanic pathways of platelet activation JO: Biomech Model Mechanobiol http://www.kidney.de/pget.php?&tw=1&pmid=22782543 #FOAvip Platelet activation is a precursor for blood clotting, which plays leading roles in many vascular complications and causes of death. Platelets can be activated by chemical or mechanical stimuli. Mechanically, platelet activation has been shown to be a function of elevated shear stress and exposure time. These contributions can be combined by considering the cumulative stress or strain on a platelet as it is transported. Here, we develop a framework for computing a hemodynamic-based activation potential that is derived from a Lagrangian integral of strain rate magnitude. We demonstrate that such a measure is generally maximized along, and near to, distinguished material surfaces in the flow. The connections between activation potential and these structures are illustrated through stenotic flow computations. We uncover two distinct structures that may explain observed thrombus formation at the apex and downstream of stenoses. More broadly, these findings suggest fundamental relationships may exist between potential fluid mechanic pathways for mechanical platelet activation and the mechanisms governing their transport. Twit Text FOAVip Potential fluid mechanic pathways of platelet activation ????Biomech Model Mechanobiol http://www.kidney.de/pget.php?&tw=1&pmid=22782543 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22782543 #FOAvip English Wikipedia <ref>{{Cite pmid|22782543 }}</ref> Potential fluid mechanic pathways of platelet activation #MMPMID22782543 Shadden SC ; Hendabadi S Biomech Model Mechanobiol 2013[Jun]; 12 (3 ): 467-74 PMID22782543 show ga Platelet activation is a precursor for blood clotting, which plays leading roles in many vascular complications and causes of death. Platelets can be activated by chemical or mechanical stimuli. Mechanically, platelet activation has been shown to be a function of elevated shear stress and exposure time. These contributions can be combined by considering the cumulative stress or strain on a platelet as it is transported. Here, we develop a framework for computing a hemodynamic-based activation potential that is derived from a Lagrangian integral of strain rate magnitude. We demonstrate that such a measure is generally maximized along, and near to, distinguished material surfaces in the flow. The connections between activation potential and these structures are illustrated through stenotic flow computations. We uncover two distinct structures that may explain observed thrombus formation at the apex and downstream of stenoses. More broadly, these findings suggest fundamental relationships may exist between potential fluid mechanic pathways for mechanical platelet activation and the mechanisms governing their transport. |Biomechanical Phenomena [MESH] |Computer Simulation [MESH] |Constriction, Pathologic/physiopathology [MESH] |Hemorheology/*physiology [MESH] |Humans [MESH]Potential fluid mechanic pathways of platelet activation (epmc).pdf DeepDyve Pubget Overpricing