Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28928888
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cancer
2017 ; 8
(15
): 2966-2973
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Potential Roles of Peripheral Dopamine in Tumor Immunity
#MMPMID28928888
Zhang X
; Liu Q
; Liao Q
; Zhao Y
J Cancer
2017[]; 8
(15
): 2966-2973
PMID28928888
show ga
Recent years, immunotherapy has turned out to be a promising strategy against
tumors. Peripheral dopamine (DA) has important roles in immune system among tumor
patients. Accumulated reports demonstrate variable expression and distribution of
DA receptors (DRs) in diverse immune cells. Interestingly, peripheral DA also
involves in tumor progression and it exerts anticancer effects on
immunomodulation, which includes inflammasomes in cancer, function of immune
effector cells, such as T lymphocytes, myeloid-derived suppressor cells (MDSCs),
tumor-associated macrophages (TAMs) and natural killer (NK) cells. Given the
specific immunologic status, DA medication may be a valuable candidate in
pancreatic cancer treatment. The major purpose of this review is to discuss the
novel potential interactions between peripheral dopamine and tumor immunity.