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10.7150/jca.20850

http://scihub22266oqcxt.onion/10.7150/jca.20850
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suck abstract from ncbi


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pmid28928888
      J+Cancer 2017 ; 8 (15 ): 2966-2973
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  • Potential Roles of Peripheral Dopamine in Tumor Immunity #MMPMID28928888
  • Zhang X ; Liu Q ; Liao Q ; Zhao Y
  • J Cancer 2017[]; 8 (15 ): 2966-2973 PMID28928888 show ga
  • Recent years, immunotherapy has turned out to be a promising strategy against tumors. Peripheral dopamine (DA) has important roles in immune system among tumor patients. Accumulated reports demonstrate variable expression and distribution of DA receptors (DRs) in diverse immune cells. Interestingly, peripheral DA also involves in tumor progression and it exerts anticancer effects on immunomodulation, which includes inflammasomes in cancer, function of immune effector cells, such as T lymphocytes, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and natural killer (NK) cells. Given the specific immunologic status, DA medication may be a valuable candidate in pancreatic cancer treatment. The major purpose of this review is to discuss the novel potential interactions between peripheral dopamine and tumor immunity.
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