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Posttesticular sperm maturation, infertility, and hypercholesterolemia
#MMPMID26067871
Whitfield M
; Pollet-Villard X
; Levy R
; Drevet JR
; Saez F
Asian J Androl
2015[Sep]; 17
(5
): 742-8
PMID26067871
show ga
Cholesterol is a key molecule in the mammalian physiology of especial particular
importance for the reproductive system as it is the common precursor for steroid
hormone synthesis. Cholesterol is also a recognized modulator of sperm functions,
not only at the level of gametogenesis. Cholesterol homeostasis regulation is
crucial for posttesticular sperm maturation, and imbalanced cholesterol levels
may particularly affect these posttesticular events. Metabolic lipid disorders
(dyslipidemia) affect male fertility but are most of the time studied from the
angle of endocrine/testicular consequences. This review will focus on the
deleterious effects of a particular dyslipidemia, i.e., hypercholesterolemia, on
posttesticular maturation of mammalian spermatozoa.