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10.1101/cshperspect.a012633 http://scihub22266oqcxt.onion/10.1101/cshperspect.a012633 C3683899!3683899 !23545421     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23545421 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Biol 2013 ; 5 (4 ): a012633 Nephropedia Template TP {{tp|p=23545421 |t=2013. Postreplicative mismatch repair |pdf=|usr=}}{{23545421 }} gab.com Text Postreplicative mismatch repair JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545421 #FOAvip The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR improves the fidelity of replication by several orders of magnitude. It also addresses mispairs and strand misalignments arising during recombination and prevents synapses between nonidentical DNA sequences. Unsurprisingly, MMR malfunction brings about genomic instability that leads to cancer in mammals. But MMR proteins have recently been implicated also in other processes of DNA metabolism, such as DNA damage signaling, antibody diversification, and repair of interstrand cross-links and oxidative DNA damage, in which their functions remain to be elucidated. This article reviews the progress in our understanding of the mechanism of replication error repair made during the past decade. Twit Text FOAVip Postreplicative mismatch repair ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23545421 #FOAvip English Wikipedia <ref>{{Cite pmid|23545421 }}</ref> Postreplicative mismatch repair #MMPMID23545421 Jiricny J Cold Spring Harb Perspect Biol 2013[Apr]; 5 (4 ): a012633 PMID23545421 show ga The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR improves the fidelity of replication by several orders of magnitude. It also addresses mispairs and strand misalignments arising during recombination and prevents synapses between nonidentical DNA sequences. Unsurprisingly, MMR malfunction brings about genomic instability that leads to cancer in mammals. But MMR proteins have recently been implicated also in other processes of DNA metabolism, such as DNA damage signaling, antibody diversification, and repair of interstrand cross-links and oxidative DNA damage, in which their functions remain to be elucidated. This article reviews the progress in our understanding of the mechanism of replication error repair made during the past decade. |*Base Pair Mismatch [MESH] |*DNA Mismatch Repair [MESH] |*DNA Repair [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |DNA Damage [MESH] |DNA/metabolism [MESH] |Escherichia coli Proteins/genetics [MESH] |Escherichia coli/genetics/metabolism [MESH] |Humans [MESH] |Molecular Sequence Data [MESH] |MutS DNA Mismatch-Binding Protein/genetics [MESH] |Protein Conformation [MESH] |Recombination, Genetic [MESH] |Reproducibility of Results [MESH] |Sequence Homology, Amino Acid [MESH]Postreplicative mismatch repair (epmc).pdf DeepDyve Pubget Overpricing