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2014 ; 29
(3
): 414-25
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Postperfusion lung syndrome: physiopathology and therapeutic options
#MMPMID25372917
Yuan SM
Rev Bras Cir Cardiovasc
2014[Jul]; 29
(3
): 414-25
PMID25372917
show ga
Postperfusion lung syndrome is rare but can be lethal. The underlying mechanism
remains uncertain but triggering inflammatory cascades have become an accepted
etiology. A better understanding of the pathophysiology and the roles of
inflammatory mediators in the development of the syndrome is imperative in the
determination of therapeutic options and promotion of patients' prognosis and
survival. Postperfusion lung syndrome is similar to adult respiratory distress
syndrome in clinical features, diagnostic approaches and management strategies.
However, the etiologies and predisposing risk factors may differ between each
other. The prognosis of the postperfusion lung syndrome can be poorer in
comparison to acute respiratory distress syndrome due to the secondary multiple
organ failure and triple acid-base imbalance. Current management strategies are
focusing on attenuating inflammatory responses and preventing from pulmonary
ischemia-reperfusion injury. Choices of cardiopulmonary bypass circuit and
apparatus, innovative cardiopulmonary bypass techniques, modified surgical
maneuvers and several pharmaceutical agents can be potential preventive
strategies for acute lung injury during cardiopulmonary bypass.