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2016 ; 26
(2
): e3667
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Postnatal Evaluation and Outcome of Prenatal Hydronephrosis
#MMPMID27307966
Sadeghi-Bojd S
; Kajbafzadeh AM
; Ansari-Moghadam A
; Rashidi S
Iran J Pediatr
2016[Apr]; 26
(2
): e3667
PMID27307966
show ga
BACKGROUND: Prenatal hydronephrosis (PNH) is dilation in urinary collecting
system and is the most frequent neonatal urinary tract abnormality with an
incidence of 1% to 5% of all pregnancies. PNH is defined as anteroposterior
diameter (APD) of renal pelvis ? 4 mm at gestational age (GA) of < 33 weeks and
APD ? 7 mm at GA of ? 33 weeks to 2 months after birth. All patients need to be
evaluated after birth by postnatal renal ultrasonography (US). In the vast
majority of cases, watchful waiting is the only thing to do; others need medical
or surgical therapy. OBJECTIVES: There is a direct relationship between APD of
renal pelvis and outcome of PNH. Therefore we were to find the best cutoff point
APD of renal pelvis which leads to surgical outcome. PATIENTS AND METHODS: In
this retrospective cohort study we followed 200 patients 1 to 60 days old with
diagnosis of PNH based on before or after birth ultrasonography; as a prenatal or
postnatal detected, respectively. These patients were referred to the nephrology
clinic in Zahedan Iran during 2011 to 2013. The first step of investigation was a
postnatal renal US, by the same expert radiologist and classifying the patients
into 3 groups; normal, mild/moderate and severe. The second step was to perform
voiding cystourethrogram (VCUG) for mild/moderate to severe cases at 4 - 6 weeks
of life. Tc-diethylene triamine-pentaacetic acid (DTPA) was the last step and for
those with normal VCUG who did not show improvement in follow-up examination, US
to evaluate obstruction and renal function. Finally all patients with
mild/moderate to severe PNH received conservative therapy and surgery was
preserved only for progressive cases, obstruction or renal function ?35%. All
patients' data and radiologic information was recorded in separate data forms,
and then analyzed by SPSS (version 22). RESULTS: 200 screened PNH patients with
male to female ratio 3.5:1 underwent first postnatal control US, of whom 65% had
normal, 18% mild/moderate and 17% severe hydronephrosis. 167 patients had VCUG of
whom 20.82% with VUR. 112 patients performed DTPA with following results: 50
patients had obstruction and 62 patients showed no obstructive finding. Finally
54% of 200 patients recovered by conservative therapy, 12.5% by surgery and
remaining improved without any surgical intervention. CONCLUSIONS: The best
cutoff point of anteroposterior renal pelvis diameter that led to surgery was 15
mm, with sensitivity 88% and specificity 74%.