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2018 ; 12
(1
): 31-34
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Post-conditioning hormesis creates a "subtraction to background" disease process:
biological, aging, and environmental risk assessment implications
#MMPMID29344792
Calabrese EJ
J Cell Commun Signal
2018[Mar]; 12
(1
): 31-34
PMID29344792
show ga
The interaction of background disease processes with environmental induced
diseases has long been an issue of considerable interest and debate with respect
to its impact on risk assessment. Whether and to what extent these processes
should be considered independent or additive to background has been the principal
focus of debate. The concept of hormesis, a biphasic dose response characterized
by a low dose stimulation and a high dose inhibition, as framed within the
context of post-conditioning, reveal the occurrence of a third type of
"background" possibility, that of "subtraction to background". This novel
application of the hormesis concept, which is framed within the biological
context of post-conditioning adaptive processes, offers considerable implications
for the assessment of aging and environmental risk assessment.