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2016 ; 5
(4
): 602-6
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Post orgasmic illness syndrome (POIS)
#MMPMID27652231
Waldinger MD
Transl Androl Urol
2016[Aug]; 5
(4
): 602-6
PMID27652231
show ga
Men with post orgasmic illness syndrome (POIS) become ill rather immediately
after ejaculation, whether spontaneously at night, during sexual intercourse or
masturbation. Two subtypes are distinguished: primary and secondary POIS. It also
occurs before or after a man has been sterilized. POIS is an invalidating most
probably auto-immune disease leading to much distress in males and their
partners. It is characterized by five criteria. Its symptoms are described by
seven clusters. However, the manifestation of these symptoms varies from one male
to the other but is relatively constant in the person himself. Among men the
symptoms vary in intensity, durations and sort of symptoms. POIS is a chronic
disorder that manifests itself in POIS "attacks" that occur within a few minutes
to a few hours after ejaculation, and disappear spontaneously after 3 to 7 days.
POIS is not associated with increased total serum IgE concentrations. On the
contrary, there are indications that POIS is triggered by specific cytokines that
are released by an auto-immune reaction to the man's seminal fluid. Indirect
clinical evidence suggests that the antigen (Ag) triggering the POIS systemic
reaction is not bound to spermatozoa but to seminal fluid produced by prostatic
tissue. In addition, POIS may also occur-although rarely-in females. In those
cases, it is hypothesized that the Ag is associated with female prostatic tissue
around the vagina.
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